Best Nootropics for Anxiety and Depression in 2022

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If you suffer from anxiety and depression, you don’t have to turn to addictive and dangerous drugs. Using nootropics, you can take a safe and holistic approach to deal with such mental issues. Today, we want to review the top contenders for the best nootropics for anxiety and depression.  

Comparison Chart

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Natural Stacks Dopamine Brain Food Supplement – Boost Your Mental Drive – Formulated to Feel Alert & Engaged – L-Phenylalanine and L-Tyrosine to Increase Motivation – Natural Dopamine Support, 60caps
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Multi Award Winning Patented NAD+ Booster Supplement More Efficient Than NMN – Nicotinamide Riboside for Cellular Energy Metabolism & Repair. Vitality, Muscle Health, Healthy Aging
41t59US29hL. SL500
Bright Vitamin – Nootropic Supplement & Brain Booster – Mental Sharpness, Focus, Energy, Memory & Mood Balance – Alpha GPC, L-Theanine, ALCAR, NALT, Vitamin D – 90 Capsules
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Zenium Anti-Stress & Anxiousness Relief Supplement | Sleep Better | Valerian Root, Ashwagandha, L-Theanine, GABA, 5HTP, Rhodiola Rosea |60 Capsules | Natural Calm Nootropic Item | Muscle Relaxer Pills
411JetpvaHL. SL160
Genius Joy – Nootropic Supplement w/Sam-e, Panax Ginseng & L-Theanine – 100 veggie pills

Best Nootropics for Anxiety and Depression: Reviews

1. Natural Stacks Dopamine Brain Food Supplement

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If you need something to help regulate your mood, and to help keep anxiety and depression in check, this might be a product for you. This dopamine enhancer also has many other mental benefits for you to reap.


This is a natural dopamine booster that is made primarily out of L-Phenylalanine and L-Tyrosine. These are special types of amino acids that the body needs to function properly. Moreover, this product also contains many different B vitamins.

Those amino acids mentioned above, they are essential for the production of dopamine. Dopamine is of course an important brain chemical. It is a mood regulator, it reduces anxiety and depression, and it makes you feel happier overall.

At the same time, increased dopamine levels also help to increase energy and stamina. Moreover, dopamine also has other notable mental benefits. It can help to increase mental clarity, problem solving capabilities, memory, and focus as well. Let’s not forget that amino acids are also essential in muscle growth and maintenance.

This product comes to us from an open source company that is extremely transparent. All ingredients are third party lab tested, as is the final product.

Simply put, this product actually contains the ingredients it claims to contain. This is not something that can be said for all such supplements out there. On a side note, for those that are gluten sensitive, this product contains no gluten. This product is also totally vegan.

You may also appreciate the fact that this product is very easy to take. All you have to do is to take 3 capsules in the morning with a glass of water.


  • Natural ingredients
  • Third party tested
  • Vegan and gluten free
  • Easy to take
  • Both mental and physical benefits


  • Short shelf life

2. Tru Niagen NAD+ Booster

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If you need something that can help boost energy while also relieving depression and anxiety, then this product might be right for you. Tru Niagen actually comes complete with a very long list of benefits, both for the brain and the body.


Ok, so this one is a bit complicated, so we’re going to do our best to simplify. Tru Niagen NAD+ Booster is a product designed to increase the levels of NAD+ in the human body. NAD+ stands for Nicotinamide adenine dinucleotide. This is a central metabolic coenzyme that is essential in cellular energy metabolism, cell formation, and energy production.

Because this chemical helps to improve cellular energy metabolism and cellular reproduction, it has benefits for virtually every part of the human body. As far as the brain goes, faster functioning cells means having better memory, focus, and overall cognitive function.

This increased cellular metabolism can also help increase dopamine and serotonin levels. Both of these substances are known for being effective mood regulators. They’re some of the strongest defenses against depression and anxiety out there.

Moreover, Tru Niagen also helps to greatly increase energy levels as well. The fact here is that this product does actually work as advertised. It is backed by over 25 different patents, by over 175 different published research studies, and even two Nobel Prize winners.

It is also shown that this product is by far the safest way to elevate your levels of NAD+. This product has been thoroughly researched and is proven to be safe for constant human consumption. It’s also really easy to take, because you just have to take 1 capsule per day. Do keep in mind that these capsules are also vegetarian.


  • Promoted cognitive function
  • Regulates mood
  • Increases energy
  • Various physical benefits
  • Backed by real evidence
  • Proven to be safe


  • Some people have trouble sleeping

3. Bright Vitamin Nootropic

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Here we have a nootropic product designed to provide you with many different mental benefits. Not only can it function as a mood regulator, but also to enhance cognitive capabilities.


This product contains a variety of natural ingredients with proven mental benefits. These ingredients include Acetyl-L-Carnitine, Acetyl-L-Carnitine, Alpha-GPC, L-Theanine, and caffeine. It does also include vitamin D as well as magnesium.

These ingredients work in combination to provide the human body and brain with a number of different benefits. It does have some caffeine, so it does help to provide you with tons of energy. Moreover, this is a lightweight stimulant that doesn’t produce any jitters, and it doesn’t cause you to crash afterwards either.

Next, this product is also known for increasing athletic performance. It has the ability to help muscles recover faster post workout. This is of course due to the fact that Bright Vitamin contains many different amino acids. These amino acids are essential for the healthy function of muscles and connective tissues. They also help to increase overall cognitive function.

The various ingredients contain its product are also effective at increasing focus, mental clarity, memory, and overall cognitive function.

These ingredients are also known to help increase dopamine and serotonin levels in the human body. Therefore, this nutritional supplement is also a fantastic mood regulator that can help control anxiety and depression.

Keep in mind that this nootropic product is made in a GMP certified facility, as well as an FDA registered facility. Moreover, this nootropic product is also made in the USA.


  • Great mood regulator
  • Increases cognitive function
  • Increases athletic performance
  • Made in the USA
  • Easy to take capsules
  • Capsules are vegetarian


  • Fairly expensive
  • May result in headaches

4. Zenium Anti-Stress & Anxiousness Relief Supplement

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Here we have a nootropic product that specifically focuses on relieving stress, anxiety, and depression. It’s also something that can help deal with insomnia and help you get a much better night’s sleep.


The Zenium Anti-Stress & Anxiousness Relief Supplement contains a number of highly effective and beneficial ingredients. These include, but are not limited to, Ashwagandha, 5-HTP, L-Theanine, GABA, Magnesium, Rhodiola Rosea, Lemon Balm, Valerian Root, Gotu Kola. We can’t explain what each of these are in so little time, but we can talk about the benefits that they produce.

The main benefit that this product has is that it helps to increase dopamine and serotonin levels in the body. Dopamine and serotonin are both extremely important in terms of mood regulation. They produce feelings of joy and elation, while also decreasing elements of depression, stress, and anxiety.

At the same time, the included ingredients also help to decrease cortisol levels in the brain. Cortisol is known for being a stress chemical. In other words, cortisol is stress. Therefore, this product helps to decrease stress levels.

This product is known for having a very calming and relaxing effect on the body. This nootropic product also has other mental benefits, including increased memory, focus, and overall cognitive abilities.

Zenium can also help provide you with a little more energy to help get you through a long day. Although you will feel more energetic throughout the day, this product is also known for helping people to sleep much better during the night.


  • Relieves stress, anxiety, and depression
  • Helps you sleep better
  • Improves cognitive abilities
  • Very easy to take
  • Safe and effective


  • Gives some people upset stomach

5. Genius Joy – Nootropic Supplement

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This nootropic supplement is designed to have two main benefits. One benefit is to help increase cognitive abilities, and the other is to help decrease stress, anxiety, and depression.


Genius Joy contains a variety of ingredients that have many benefits for the human mind. Just some of the ingredients here include complex B vitamins, Vitamin D, 5-HTP, SAM-e, rhodiola, ginseng, s-adenosylmethionine, and more. Once again, there are too many ingredients to explain them all, but we can certainly talk about the benefits.

One of the best ingredients here is 5 HTP, which is proven g to help increase both serotonin and dopamine levels. This in turn helps to decrease stress, anxiety, and depression.

Moreover, this substance also helps to increase melatonin production, which therefore helps you sleep much better. This substance is also known for helping to decrease symptoms of fibromyalgia and migraines.

The various other ingredients contained in this nootropic supplement also help to increase mental clarity, problem solving capabilities, focus, memory, and more. The various ingredients here are excellent for increasing cognitive abilities.

Moreover, many of the ingredients included here do also have physical health benefits. You will definitely have more energy when you take this product, although it is calm energy. This means that you will still be able to sleep at night.


  • Decreases stress, anxiety, and depression
  • Improves mood
  • Improves cognitive function
  • Has physical health benefits
  • Safe
  • Made in the USA


  • Expensive
  • May cause upset stomach


If you want a natural, safe, and effective way to help anxiety, depression, and stress, we recommend the Natural Stacks Dopamine Brain Food Supplement. That said, all five of the nootropics we reviewed today have various benefits, both for your mind and body.

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